Piccolis and colleagues found that RNF213 depletion reduced palmitate-mediated cytotoxicity by approximately 50%, and knockdown of RNF213 attenuated the cell death induced by palmitate in hepatocellular carcinoma-derived cell line 2 (HepG2) cells and suspended mammary 159 pleural effusion (SUM159) cells (Piccolis et al., 2019). Here, RNF213 is linked to hepatocellular carcinoma.