LDLR and atherosclerosis: To examine whether co-presence of human AGT and renin in PTCs contributed to atherosclerosis, Kap-hAGT, Kap-hREN, Kap-hAGT × Kap-hREN, and their wild type littermates in an LDL receptor −/− background were fed Western diet for 8 weeks beginning two weeks after testosterone pellet implantation.