Abnormal LAMP‐2A‐stained lysosomal nuclear aggregation was observed in the striatum of mice with mutations in LRRK2 (leucine‐rich repeat kinase‐2) (also known as PARK8), the pathogenic gene of PD, suggesting impaired degradation of abnormal proteins by the lysosomal pathway.165, 166. This evidence concerns the gene LRRK2 and Parkinson disease.