In colorectal cancer, five‐fluorouracil (5‐FU) was found to reduce the binding ability of histone acetyltransferase E1A‐binding protein and CREB‐binding protein (p300/CBP) to chromatin and induce its degradation through CMA, thereby inducing histone deacetylation in colorectal cancer cells.213. Here, EP300 is linked to colorectal cancer.