GJA1 and nasopharyngeal carcinoma: As seen in Figures 4A–E, D4 (500 nM) treatment of neurosphere-derived cells did not significantly affect BrdU incorporation (26.5 ± 5.8% in control cultures vs 31.4 ± 4.2% in cultures treated with 500 nM D4, n = 8, p > 0.05), which suggests that Cx43 hemichannel inhibition is not relevant for NPC proliferation.