Mapping relation examination between COVID-19 and Ephedra-Glycyrrhiza exhibited that the key markers were tumor necrosis factor-α (TNF-α), interleukin-2 (IL-2), albumin (ALB), FOS proto-oncogene, and prostaglandin- endoperoxide synthase 2 (PTGS2). The gene discussed is PTGS2; the disease is COVID-19.