NPPB and pericardial effusion: According to McGoon et al., worse prognostic outcomes include >65-year-old males with etiologically CTD, a higher WHO FC or NYHA FC, a more elevated B-type natriuretic peptide (BNP) level and N terminal pro-BNP level (NT pro-BNP), radiologically pericardial effusion on echocardiography, and a lower predicted value.