A new insight came into the H. pylori and migraine conundrum when Gasbarrini and colleagues conducted another study, this time a high-quality study, and found that although the prevalence of H. pylori was similar in both migraine patients and controls, there was a significant increase in prevalence of the virulent Cag-A positive strains of H. pylori in migraine patients with aura compared to those without aura or in controls [17]. This evidence concerns the gene S100A8 and migraine disorder.