We did not find significant associations between the TNFα SNPs at position -308, -857, -863, and -1031 and the therapeutic efficacy of ADA in Chinese patients with AS, although there was a trend for association with the TNFα -857 T allele, which was previously found to be associated with better treatment response to etanercept in patients with RA [20]. This evidence concerns the gene ADA and rheumatoid arthritis.