From our previous study, we have concluded VGSC α2 (Nav1.2), GABA receptor α1-β1 (GABAr α1-β1), and VGCC α1G (CAV3.1) as major epilepsy target proteins for multi-targeted epilepsy therapy [20].Protein tertiary structures of Nav1.2, GABA receptor α1, and Cav3.1 were available on the PDB database with PDB IDs: 6J8E-A, 6HUJ-A, and 6KZP, respectively. The gene discussed is CACNA1G; the disease is epilepsy.