Further work is required to confirm Notch down regulation and clarify the role of Notchsignaling in etoposide resistance in AML Enzymes of amino acid metabolism such as ornithine amino transferase (OAT) are emerging as important therapeutic targets that work by disrupting the metabolic machinery of cancer cells and depriving them of essentialnutrients for their growth and survival. Here, OAT is linked to acute myeloid leukemia.