In the INTERHEART and INTERSTROKE study, hypertension accounted for 17.9%and 34.6% of population attributable risk for coronary artery disease and stroke respectively.CRP appears in serum in response to a variety of inflammatory stimuli .Raised level of hs-CRP is seen with increasing with age, during an infection, inflammation,coronary artery diseases, obesity, sepsis, smoking and vasculitis. The gene discussed is CRP; the disease is coronary artery disorder.