Many investigators have evaluated new markers like pro-calcitonin, cytokines, cell surface antigens for rapid diagnosis of sepsis, but their use in routine practice are limited by the lack of resourcesin developing countries [5-7] .C -Reactive protein and Total leukocyte counts (WBC) are frequently used for diagnosing neonatal sepsis, but a single value of CRP and WBC alone notsufficient to include and exclude sepsis. Here, CALCA is linked to Sepsis.