In present study, serum adiponectin levels were measured in patients with type 2 diabetes mellitus who were classified further based on the amount of protein excretion into three groups and the levels were compared with age and gender matched healthy controls.Serum adiponectin significantly elevated levels were detected in patients with T2DM in the pre nephropathy stage and it was significantly higher levels were found from normoalbuminuria stage to macroalbuminuria stage when compared to healthy individualsrespectively P = 0.0001** (Table 2 - see PDF) (Figure 1 - see PDF). This evidence concerns the gene ADIPOQ and kidney disorder.