The result of our study also reveals Defective B4GALT7 causes EDS, progeroid type, Defective B3GAT3 causes JDSSDHD, and Defective B3GALT6 causes EDSP2 and SEMDJL1 pathways which are associated with aged appearance, developmental delay, broad spectrum of skeletal, connective tissue and wound healing problems (Fabregat et al., 2018). This evidence concerns the gene B3GAT3 and Global developmental delay.