The pathways include Defective CHSY1 causes TPBS, Defective CHST3 causes SEDCJD, Defective CHST14 causes EDS, musculocontractural type to name a few (Fabregat et al., 2018). This evidence concerns the gene CHSY1 and spondyloepiphyseal dysplasia with congenital joint dislocations.