NOS3 and Mental deterioration: Austin and Katusic (2020) used endothelial nitric oxide synthase (eNOS) heterozygotic knockout (+/−) mice, demonstrating that increased cerebrovascular Aβ is caused by a partial decrease of endothelial nitric oxide. According to Cao et al. (2019) loss of a disintegrin and metalloprotease with thrombospondin type I motif, member 13 (ADAMTS13) led to greater cognitive decline in APP/PS1 mice by speeding up CAA by blocking BBB-mediated Aβ clearance from the brain.