Tarawneh et al. (2022) found that increased vascular endothelial-cadherin was associated with Aβ, tau, neurodegeneration in preclinical AD. According to research by Yamazaki et al., synaptic degeneration is associated with the loss of TJs proteins, which is a prevalent occurrence in AD (Yamazaki et al., 2019). Here, MAPT is linked to Alzheimer disease.