For example, Gem was shown to be upregulated during nerve injury to reduce PQ channel activity and likely reduce regenerating neurite branching during regeneration (Wang et al., 2013; Scamps et al., 2015), and Gem-mediated inhibition of L-type channels was shown to control light-induced phase shifts in circadian rhythms in the suprachiasmatic nucleus (Matsuo et al., 2022). The gene discussed is GEM; the disease is injury.