Irisin and cathepsin B (CTSB) are both myokines released from EVLs during exercise (Safdar and Tarnopolsky, 2018) that have been shown to improve memory and induce adult neurogenesis in the hippocampus via induction of brain-derived neurotrophic factor (BDNF) (Moon et al., 2016), proving to be neuroprotective in AD patients by reducing β-Amyloid Peptide (the main component of amyloid plaques) levels, although this remains controversial (Morris et al., 2014; Selkoe and Hardy, 2016; Chen et al., 2017). This evidence concerns the gene CTSB and Alzheimer disease.