JUND and neoplasm: CTCF and JunD MIRA scores were also more strongly correlated with gene expression–based keratinization than with their respective gene expression levels (CTCF: Pearson R = 0.29, P = 0.091; JunD: Pearson R = 0.27, P = 0.11), and CTCF and JunD were not differentially expressed between tumor subtypes (Fig. 6F), illustrating how MIRA scores provide regulatory information that is not captured by gene expression levels alone.