Of the 11 neoplasm-related genes in these subclusters, the expression of six (ANGPT2, TP73, NOVA1, CDH11, CXCL12, and LAMA1) were significantly repressed in KRT and one (EPHA2) was higher expressed in KRT compared with IMU (Supplementary Fig. S7). Here, ANGPT2 is linked to neoplasm.