NFKB1 and head and neck squamous cell carcinoma: The canonical NFκB was reported to be a potential target in HNSCC tumors (50); however, it was also observed that inducing the noncanonical NFκB pathway, which was upregulated in HPV(+) tumors, resulted in more IL12-producing dendritic cells and sensitized tumors to anti-PD-1 therapy (51).