CTCF and JunD MIRA scores were also more strongly correlated with gene expression–based keratinization than with their respective gene expression levels (CTCF: Pearson R = 0.29, P = 0.091; JunD: Pearson R = 0.27, P = 0.11), and CTCF and JunD were not differentially expressed between tumor subtypes (Fig. 6F), illustrating how MIRA scores provide regulatory information that is not captured by gene expression levels alone. This evidence concerns the gene CTCF and neoplasm.