Sinatra et al. utilised their novel solid phase synthesis approach to hydroxamic acid-based PROTACs in an attempt to discover PROTACs to selectively degrade HDAC6.82 They identified 26 and 27 with DC50 values of 3.5 nM and 19.4 nM respectively for HDAC6 in the leukaemia HL-60 cell line. The gene discussed is HDAC6; the disease is leukemia.