Despite their role in histone deacetylation, the name Histone Deacetylase can perhaps be deceptive as the substrate specificity of HDACs can expand beyond histone proteins to non-histones such as p53, signal transducer and activator of transcription 3 (STAT3), the androgen receptor (AR) and α-tubulin as a few select examples.5–8 p53, STAT3 and AR are important transcription factors whereby their overexpression or mutation can be associated with many cancers.9–11 While α-tubulin, another important cancer drug target, is a central component of the cytoskeleton and important for cell division.12 This evidence concerns the gene STAT3 and cancer.