Zhao et al. reported a highly potent HDAC8 targeting PROTAC with a single digit nanomolar DC50 value of 1.8 nM and Dmax value of 97% in MDA-MB-231 breast cancer cell line.6816 was also a degrader of HDAC6 but with a higher DC50 value of 38 nM. The gene discussed is HDAC6; the disease is breast carcinoma.