A final approach is the Delta One T (DOT) cell-generating protocol, which includes a three-week TCR stimulation with cytokines (anti-CD3 antibody with IL-4, IFNγ, IL-21, and IL1-β) and generates Vδ1T cells that express cytotoxicity-associated NK cell receptors (NKG2D, DNAM-1, NKp30, and NKp4) and can eliminate human AML xenografts (182). Here, IL21 is linked to acute myeloid leukemia.