Intriguingly, keratinocytes from psoriatic skin exhibited a reduced level of TSP-1 (46), and TSP-1 expression in psoriasis patients was inversely correlated with disease activity, which was related to the dysregulated expression of TSP-1 in the immune cells and inhibition of Th17 differentiation (Table 1) (47). Here, THBS1 is linked to psoriasis.