GZMB and neoplasm: In the α4-1BB/AlloDC combination group, we observed an overall higher infiltration of CD8 T-cells (Figures 2F, 3A, B), especially TRM (Figures 3H, I), which was shown to control tumor growth by producing granzyme B and IFN-γ for the direct killing of tumors, eliciting the production of chemokines and expression of adhesion molecules (28).