CD8A and cancer: Standard and metronomic chemotherapy, such as oxaliplatin and doxorubicin, induce positive immunomodulatory effects in the TME and can enhance the antitumor immune responses elicited by cancer vaccines, by inhibiting the immunosuppressive cells (i.e., Tregs and MDSCs) and increasing interferon gamma (IFN-γ) secreting CD8+ T cells.