Exposure of HFLS-RA cells to Mφ-SNFIB-MAA-CIT increased phosphorylation (p-) of JNK (3-fold, p<0.05 vs. Mφ-SNFIB), Erk1/2 (6-fold, p<0.01), and Akt (2-fold, p<0.05) at 1-h. Here, MAPK3 is linked to rheumatoid arthritis.