Studies have demonstrated that ERFE is a glycoprotein hormone secreted by erythroblasts in response to erythropoietin (EPO) stimuli such as hemorrhage, hypoxia, EPO therapy, β-thalassemia, and anemia of inflammation, and it suppresses the hepatic production of hepcidin, thereby mobilizing iron for erythropoiesis (27). This evidence concerns the gene HAMP and hemorrhage.