In fact, these recent studies, performed in transfected cell lines, have disclosed mild modifications of gating properties for these mutants, which do not show clear correlation with the phenotypes within the NDEEMA‐EIDEE/MD‐EIDEE‐focal seizures spectrum and are, in general, smaller than those observed for S/FHM SCN1A/NaV1.1 variants in the same experimental conditions (Brunklaus et al., 2022; Matricardi et al., 2023). This evidence concerns the gene SCN1A and Seizure.