In fact, pathogenic variants of SCN1A/NaV1.1, SCN2A/NaV1.1, SCN3A/NaV1.1, SCN8A/NaV1.6, and SCN1B/β1, which are expressed in the central nervous system, are important causes of different types of epilepsies, including mild and severe forms (Brunklaus & Lal, 2020; Mantegazza et al., 2021; Meisler et al., 2021). This evidence concerns the gene SCN3A and epilepsy.