Missense SCN1A/NaV1.1 variants can also cause sporadic/familial hemiplegic migraine type3 (S/FHM3), a rare form of migraine with aura with onset in adolescence, characterized by hemiparesis as part of the aura phase (Dichgans et al., 2005; Ferrari et al., 2015; Mantegazza & Cestele, 2018). Here, SCN1A is linked to migraine disorder.