VEGFA and melanoma: Andrographolide decreased tumor-specific angiogenesis by lowering the manufacture of the pro- and anti-angiogenic factors such as interleukin-2, vascular endothelial growth factor, nitric oxide, and tumor necrosis factor TNF-α, in the C57BL/6 mice infected with the B16F-10 melanoma cells (Table 1) [75].