Neovascularization is considered to be one of the main factors in the formation and maintenance of pannus in RA, and some studies have shown that VEGF can increase vascular permeability and play a very critical role in the formation and development of pannus in RA synovitis.[19,20] Furthermore, it is important in promoting the formation and development of inflammation, especially for the formation of chronic inflammation. This evidence concerns the gene VEGFA and rheumatoid arthritis.