It has been reported that NAC can increase the pCR rate in HER2-positive and TNBC, leading to significantly improved survival rates for patients.[23] The role of NAC has been further expanded within breast cancer subtypes, and even the application of immunotherapy for breast cancer has led to more improved survival results.[24] However, the role of NAC in the luminal B subtype is still not fully understood. This evidence concerns the gene ERBB2 and breast cancer.