However, accumulating evidence suggests that triggers such as pressure or volume overload or myocardial diseases such as RV infarction or cardiomyopathy contribute to the activation of inflammatory pathways.[13] Moreover, Harhay et al demonstrated in an interesting magnetic resonance imaging investigation that plasma levels of pro-inflammatory C-reactive protein and interleukin-6 were independently associated with RV morphology, even in individuals without cardiovascular disease.[14]. The gene discussed is CRP; the disease is cardiovascular disorder.