The enhanced activity of the IL-17 pathway is associated with the proliferation and pathogenicity of Th17 cells, and evidence from animal models has suggested that the development of pathogenic Th17 cells is responsible for experimental autoimmune uveitis.[47] The helper T cells of IL-17, specifically Th1 and Th17 cells, can promote the proliferation of Tregs and T cells, which are most abundant in MAPK and TNF signaling pathways. Here, TNF is linked to autoimmune uveitis.