VKORC1 and Hypertension: In particular, SNPs in the VKORC1 gene have been shown to affect the efficacy and safety of warfarin therapy,[9] while variants of CYP4F2 and GGCX genes have been implicated in the pathogenesis of hypertension, thrombosis, and osteoporosis.[11–14] Owing to the critical role of the key enzymes encoded by these genes, SNPs impacting their function lead to alterations in the metabolic pathways of vitamin K, which may become symptomatic in certain contexts, like in the case of the administration of various drugs such as oral anticoagulants.