CYP4F2 and diabetes mellitus: There is a complex interaction between inflammation, degradation of extracellular matrix components, neovascularization of the plaque, and the presence of comorbidities such as diabetes or chronic kidney disease.[37] Most of the plaques from our stroke patients were calcified, but this is partially explained by the increased frequency of homozygous and heterozygous genotypes of VKORC1 and CYP4F2 polymorphisms.