SOD1 and psoriasis: Psoriasis is associated with abnormalities in essential fatty acid metabolism, lymphokine release, free radical generation, and lipid peroxidation.[15,16] Trillin, a secondary metabolite identified in Dioscorea spp., may alleviate psoriasis symptoms in patients by increasing superoxide dismutase (SOD) activity and reducing lipid peroxidation and oxidative stress.[17,18] However, the scientific basis and potential pharmacological mechanisms of STT in psoriasis treatment remain unclear and require further investigation.[19,20]