The BP entry (p.adj < 0.01) of down-regulated genes in NL-LS mainly included type I interferon (IFN) signaling pathway, response to virus, skin development, and cellular response to type I IFN (Fig. 2A), suggesting that type 1 interferons (IFNα and IFNβ), key cytokines that activate autoimmunity during viral infection, may play an indispensable role in initiating psoriasis during skin injury.[29] The enriched GO-BP terms of up-regulated genes (p.adj < 0.01) are primarily associated with fatty acid metabolic processes, lipid catabolic processes, and cornification (Fig. 2B). Here, IFNB1 is linked to Autoimmunity.