EGFR and radiodermatitis: Radiation therapy is a commonly used treatment modality for various types of cancer.[1] However, a significant side effect of radiotherapy, chemotherapy, or epidermal growth factor receptor inhibitors is the development of acute radiodermatitis, which can occur after as few as 10 to 15 sessions and affects approximately 95% of patients with head and neck tumors.[2] The symptoms of acute radiodermatitis are categorized into 3 levels: grade 1 (mild erythema), grade 2 (dry desquamation), and grade 3 (severe moist desquamation).