The low expression of ATP7A, LIPT2, DLAT, MTF1, GLS, and CDKN2A in patients with HCC was associated with poor OS, and the high expression of SLC31A1, FDX1, and LIAS in patients with HCC was associated with poor OS in both TCGA (Fig. 1C) and ICGC datasets (Fig. 1F). This evidence concerns the gene GLS and hepatocellular carcinoma.