The expression of ATP7A, PDHA1, LIAS, LIPT1, GLS, LIPT2, DLD, DLAT, PDHB, MTF1, and CDKN2A was up-regulated, while the expression of SLC31A1, and FDX1 was down-regulated in HCC tissues compared with that in normal liver tissues. This evidence concerns the gene ATP7A and hepatocellular carcinoma.