In addition, we found that in ESCC, TMEM40, GRHL3, BNIPL, NECTIN4, DUOX1, and DUOXA1 are highly positively correlated with AIM1L, while LOC100506844, MPDZ, RCN1, FZD2, and FXYD6 are highly negatively correlated with AIM1L, indicating that there may be a regulatory relationship between them. The gene discussed is MPDZ; the disease is esophageal squamous cell carcinoma.