AIM1 can also inhibit the invasiveness of benign prostatic epithelium.[28] AIM1 has also been identified as a potential tumor suppressor gene for malignant melanoma,[29] and AIM1 hypermethylation is associated with poor prognosis of melanoma.[30] Therefore, based on our research on AIM1L and related research, we cautiously assume that AIM1L may inhibit the occurrence and development of ESCC. Here, CRYBG1 is linked to melanoma.