AIM1 hypermethylation is associated with bladder cancer, nasopharyngeal carcinoma, and melanoma.[25,26] However, AIM1 is highly overexpressed in prostate cancer tissue.[27] Another study on AIM1 and prostate cancer showed that advanced prostate cancer is usually accompanied by AIM1 deletion and decreased expression. This evidence concerns the gene CRYBG1 and urinary bladder cancer.