AIM1 hypermethylation is associated with bladder cancer, nasopharyngeal carcinoma, and melanoma.[25,26] However, AIM1 is highly overexpressed in prostate cancer tissue.[27] Another study on AIM1 and prostate cancer showed that advanced prostate cancer is usually accompanied by AIM1 deletion and decreased expression. The gene discussed is CRYBG1; the disease is prostate cancer.