AIM1 can also inhibit the invasiveness of benign prostatic epithelium.[28] AIM1 has also been identified as a potential tumor suppressor gene for malignant melanoma,[29] and AIM1 hypermethylation is associated with poor prognosis of melanoma.[30] Therefore, based on our research on AIM1L and related research, we cautiously assume that AIM1L may inhibit the occurrence and development of ESCC. Here, CRYBG2 is linked to esophageal squamous cell carcinoma.