Considering that (1) elevated triglyceride levels and intermittent hypoxemia can lead to increased inflammation, oxidative stress, alterations in hemodynamics, and induction of the renin‐angiotensin system, (2) increasing insulin signaling leads to increased kidney function and oxygen consumption, and (3) chronic intermittent hypoxemia may predispose individuals with OSA to kidney disease, it was hypothesized that AKI biomarkers would increase following the consumption of a high‐fat meal in individuals with OSA and healthy individuals exposed to intermittent hypoxemia. Here, REN is linked to obstructive sleep apnea syndrome.