The PCK rat, a Pkhd1 gene mutation model of human ARPKD, that has many of the phenotypic features of human ADPKD, is a good model to further understand the beneficial and adverse effects of MET in PKD and to provide insights into designing human studies (Lager et al., 2001). Here, PKHD1 is linked to autosomal recessive polycystic kidney disease.