Consistent with the differential and independent regulation of fibroblast phenotype by hypoxia and TGF‐β in normal and IPF fibroblasts, our studies indicate that hypoxia increases LDHA in normal and IPF fibroblasts while it suppresses LDHB only in the IPF fibroblasts. The gene discussed is TGFB1; the disease is idiopathic pulmonary fibrosis.