One study found that 37% of the bronchiectasis patients had a total IgE level higher than 100 IU/L, and the total IgE level was higher in patients with more severe disease [13].More interestingly, a high frequency of sensitization to multiple allergens was also demonstrated in bronchiectasis patients, and this immuno-allergic subtype was associated with poorer clinical outcomes including decreased pulmonary function and more severe disease [14]. The gene discussed is IGHE; the disease is bronchiectasis.