In randomized clinical trials (RCT), patients with T2D treated with sodium-glucose cotransporter-2 inhibitors (SGLT-2i, i.e., empagliflozin, canagliflozin, or dapagliflozin) exhibited lower risks for cardiovascular events, such as hospitalisation for heart failure (HHF), nonfatal MI, nonfatal stroke, cardiovascular mortality (CVM) and 3-point major adverse cardiovascular events (MACE: including MI, stroke, or CVM) when compared with patients using a placebo [3–5]. Here, SLC5A2 is linked to Stroke.