Kaplan–Meier survival analysis revealed that patients with high BRF2 expression had worse OS and RFS than those with low BRF2 expression (Fig. 3l, m). Analysis of BRF2 expression and clinical characteristics of TMA indicated there was a statistical correlation between BRF2 expression level and two clinicopathological features (tumor size and recurrence) (Table 1). Here, BRF2 is linked to neoplasm.