The unique subset of EGFR mutation-lacking LCNS patients in Caucasian populations coincides with a subset of LCNS tumors that have been identified to have lower tumor mutational burden (TMB) and lack somatic copy number alterations (SCNAs), structural variants, and whole genome doubling as reported by Zhang et al., termed the ‘piano’ subtype. The gene discussed is EGFR; the disease is neoplasm.