CDKN2A and lung cancer: EGFR mutations are also observed to occur frequently with CDKN2A and RB1 mutations in LCNS tumors, with loss of function variants identified in CDKN2A and RB1 at 24.4% and 16%, respectively; EGFR-positive lung cancers harboring co-mutations have been associated with increased resistance to EGFR-TKI therapy and poorer clinical outcomes than harboring EGFR mutation alone [95].