In agreement with these results, among the eight AD causal genes with either sex-biased expression or genetic regulation of protein expression that we identified, half of them are involved in immune function: CD2AP facilitates recognition of antigen by T cells42; SLMAP participates in T cell receptor signaling43; ADAM10 regulates cytokine levels in activated microglia44; and STXBP3 is involved in immune function45,46. This evidence concerns the gene ADAM10 and Alzheimer disease.