For instance, CTNND1 is a causal gene in four different psychiatric disorders (major depression, schizophrenia, post-traumatic stress disorder and problematic alcohol use) and neuroticism (a personality trait that is prone to experiencing negative emotions) and had sex-biased expression at both the transcript and protein levels in concordant directions (Fig. 3b). The gene discussed is CTNND1; the disease is post-traumatic stress disorder.