PLOD1 and amenorrhea: They also showed reproductive dysfunction, including loss of dominant follicles (0% of patients had dominant follicles in both groups), polycystic ovaries (40 vs 30%), menstrual disturbances such as amenorrhea (40 vs 30%) and oligomenorrhea (36.67 vs 43.33%), elevated blood testosterone levels, LH levels, and LH/FSH ratio.