Therefore, our unbiased dissection of key ligand-receptor interactions between CIP associated hyperinflammatory myeloid cell subclusters and effector T cell subclusters highlights CXCL, IFN, FAS, and the TNF signaling axis as important regulators within the BALF microenvironment of patients with CIP, which is also an important biomarker for the screening of CIP. The gene discussed is IFNA1; the disease is hereditary sensory and autonomic neuropathy.