Having defined CIP associated T cell and myeloid cell subpopulations, obvious correlations between the abundance of CXCL9+monocytes, LAMP3+ DCs and CIP associated T cell subclusters were found, such as CXCL13+ CD4, CXCL13+ CD8, and GZMB+ CD8 (Fig. 8A, Supplementary Fig. 5). The gene discussed is CXCL9; the disease is hereditary sensory and autonomic neuropathy.