The pseduotime trajectory analysis revealed that the differentiation of hyperinflammatory CXCL9+ monocytes to anti-inflammatory alveolar macrophages was blocked, whereas LAMP3+ DCs with high migration characteristics was highly expanded in CIP, which was derived from the differentiation of CXCL9+ monocytes (Fig. 7A–D, Supplementary Fig. 4A–C). Here, LAMP3 is linked to hereditary sensory and autonomic neuropathy.