PRF1 and hereditary sensory and autonomic neuropathy: Here, we demonstrated a dramatic accumulation of CXCL13+ CD4+ T and CXCL13+ CD8+ T cells, characterized by high expression levels of the cytotoxic effector signatures IFNG, GZMB, and PRF1, which supports previous findings that CD4+ and CD8+ T cell accumulation are hallmarks of CIP [25, 27, 37].