Gene set enrichment analysis (GSEA) of the upregulated genes showed that the differentially upregulated genes in the CIP associated CD8+ T cell subclusters compared to other CD8+ T cell subclusters were enriched in interferon signaling, IFNG, and lung proliferating NK/T cell pathways, which correlated with T cell effector function (Fig. 2H), indicating a highly cytotoxic and effective environment for CIP induced by ICIs. This evidence concerns the gene CD8A and hereditary sensory and autonomic neuropathy.