The organization of the CD8+ T cell compartment showed great differences between CIP− and CIP+ group (Fig. 2C); GZMB+ CD8, CXCL13+ CD8, and proliferating MKI67+ CD8 were more frequent in CIP+ samples, whereas naïve IL7R+ CD8 and resident ZNF683+ CD8 were more enriched in CIP− samples (Fig. 2D). Here, ZNF683 is linked to hereditary sensory and autonomic neuropathy.