Furthermore, the TCR sequences showed that CXCL13+ CD4 and CD40LG+ CD4 had more hyperexpanded TCR clonotypes (Fig. 5A–C) and CXCL13+ CD4 shared more expanded TCR clonotypes with CD40LG+ CD4 and IL7R+ CD4 (Fig. 5D), indicating that IL7R+ CD4 contributed to differentiate to CD40LG+ CD4 to CXCL13+ CD4 in CIP+ samples, whereas it differentiated to CD40LG+ CD4 but not CXCL13+ CD4 in CIP− samples. The gene discussed is CD40LG; the disease is hereditary sensory and autonomic neuropathy.