The corresponding TCR sequences revealed that GZMB+ CD8, CXCL13+ CD8 shared expanded TCR clonotypes with resident ZNF683+ CD8, with the highest clonality observed in CXCL13+ CD8 cells (Fig. 3A-D, and Supplementary Fig. 2E), In addition, CIP+ group exhibited more hyperexpanded TCR clonotypes than CIP− group, although the trend is not notably (Fig. 3B, and Supplementary Fig. 2F), indicated that CD8+ T cells undergo clonal expansion following TCR activation in patients with CIP. Here, ZNF683 is linked to hereditary sensory and autonomic neuropathy.