Interestingly, IFN-α or IFN-γ response and TNF-α genes (IFNG, STAT1, TNF) were highly expressed in CIP associated CD4+ and CD8+ T cell clusters alongside pseudotime of the T cell differentiation trajectory, with the receptor IFNGR1/2, TNFRSF1A increased alongside pseudotime of the myeloid cell differentiation trajectory. Here, IFNGR1 is linked to hereditary sensory and autonomic neuropathy.