Interestingly, the immune-checkpoint (LAG3, HAVCR2, PDCD1), immune cell-homing signals (CXCL13, CCL3/4), IFNγ response (IFNG) and cytotoxic effector (GZMB, PRF1, GNLY) markers were the top differentially expressed genes (DEGs) in CIP associated CD8+ T cell subclusters (Fig. 2F, G). The gene discussed is GZMB; the disease is hereditary sensory and autonomic neuropathy.