The proportion of these cell subtypes differed notably among patients (Fig. 6B), and CXCL9+ and SPP1+ monocyte was more frequent in the CIP+ samples than in the CIP− samples, whereas the number of FABP4+ macrophages decreased dramatically in the CIP+ samples (Fig. 6D, p < 0.05). Here, SPP1 is linked to hereditary sensory and autonomic neuropathy.