HMOX1 and neoplasm: On the other hand, recent studies have shown that enhanced HMOX1 expression leads to excessive accumulation of free cellular iron and severe lipid peroxidation, which augments ferroptosis and promotes the sensitivity of antitumor agents (Chang et al. 2018; Hassannia et al. 2018), suggested that the role of HMOX1 might be various in different tumor models.