The high-risk group scored highly in alcoholism, APM signal, cytokine-cytokine receptor interaction, homologous recombination, microRNAs in cancer, oocyte meiosis, progesterone-mediated oocyte maturation, proteasome, systemic lupus erythematosus and viral carcinogenesis, while scored lowly in IFN-γ signature than those in low-risk group (Fig. S6A). This evidence concerns the gene IFNG and alcohol dependence.