TP53 and cancer: In population controls, TP53 P/LP variants were identified in 27 of the 59,095 cases (0.05%) (Supplementary Table S1), therefore the odds to detect TP53 P/LP variant in cancer patients with multiple tumours or patients having multiplex tumours in the family but not fulfilling Chormpet A criteria was 12.5 (OR 12.5; 95% CI 4.803–32.54; p < 0.0001).