However, 4 weeks of swimming exercise significantly reduced the levels of GnRH, LH and FSH in the exercised-AD group (74.1 ± 6.1 pg/ml, 5.7 ± 0.6 mIU/ml, 9.7 ± 0.3 ng/ml, respectively) as compared to the AD group (80.9 ± 4.2 pg/ml, 7.8 ± 0.5 mIU/ml, 11.1 ± 0.4 ng/ml, respectively), p = 0.014, p < 0.001 and p < 0.001, respectively. The gene discussed is BRD2; the disease is Alzheimer disease.