NR1H4 and metabolic dysfunction-associated steatohepatitis: Remarkably, in mice with diet-induced NASH, the overexpression of miR-802 largely abolishes the beneficial reduction in hepatic inflammation, fibrosis, and apoptosis mediated by obeticholic acid (OCA), a potent agonist of the bile acid nuclear receptor farnesoid X receptor (FXR/NR1H4).